
姚静静,女,1993年8月生,博士,讲师,硕士研究生导师,毕业于广州中医药大学。现就职于山西中医药大学太行本草研究院,研究方向为有毒中药毒-效双向调控机理研究。主持国家自然科学基金青年基金项目(C类)、山西省科技厅基础研究计划项目、山西省中医药管理局科研课题、山西省高等学校科技创新项目等8项。以第一作者或通讯作者发表研究论文8篇。兼任中国中医药信息学会中药药理分会理事,山西省中医药学会心血管病分会委员。
教育工作经历
2023.11-至今,山西中医药大学,讲师
2019.09-2022.06,广州中医药大学,中药学,博士
2016.09-2019.06,河南大学,药学,硕士
研究方向
中药毒-效双向调控机理研究
科研项目
[1] 国家自然科学基金青年科学基金项目(C类),附子及乌头碱靶向调控POSTN介导药物代谢酶CYP3A4对心脏“毒-效”的双向调节作用机制研究,82505236,2026.01-2028.12,30万元,在研,主持。
[2] 山西省科技厅基础研究计划青年项目,附子乌头类生物碱靶向Periostin抑制心肌纤维化治疗心力衰竭的作用机制研究,2024.07-2027.07,5万元,在研,主持。
[3] 山西省中医药管理局科研课题,基于胞外基质蛋白探讨附子改善心力衰竭心肌纤维化的机制研究,2024ZYY2B059,2024.11-2027.11,2万元,在研,主持。
[4] 山西省高等学校科技创新项目,骨膜蛋白介导附子治疗心力衰竭药效个体差异的发现及机制研究,2024L266,2024.6.1-2026.5.31,2万元,在研,主持。
[5] 山西中医药大学科技创新能力培育计划基础与临床合作研究专项,益气活血利水方改善心力衰竭的临床及机制研究(基础研究部分),2024PY-JL-20-02,2024.09.01-2026.08.31,5万元,在研,主持。
代表性论文论著
[1] Jingjing Yao, Yajuan Guo, Ting Wan, Shaofang Yu, Qinghong Shen, Min Huang, Yu Li, Fuping Xu, Huiyan Zeng, Zhongqiu Liu*, Linlin Lu*. CYP3A4 and MRP2 are predominant metabolic regulators attribute to the toxicity/efficacy of aconitine derived from Fuzi. Journal of Ethnopharmacology. 2025:343:119463.
[2] Yajuan Guo#,Jingjing Yao#, Zhenzhen Guo, Ming Ding, Kunlin Zhang, Qinghong Shen, Yu Li, Shaofang Yu, Ting Wan, Fuping Xu, Ying Wang, Xiaoxiao Qi, Jinjun Wu, Jianxin Chen*, Zhongqiu Liu*, Linlin Lu*. HBB contributes to individualized aconitine-induced cardiotoxicity in mice via interfering with ABHD5/AMPK/HDAC4 axis. Acta Pharmacologica Sinica. 2024;45(6):1224-1236.
[3] Li Ying, Ye Lixin, Yao Jingjing*, Zhong Wanru. Association between dietary inflammatory index and depression in individuals with cardiovascular-kidney-metabolic syndrome stage 0-3: a cross-sectional study. Diabetol Metab Syndr. 2026 May 9;18(1):129.
[4] Jingjing Yao, Qinghong Shen, Min Huang, Ming Ding, Yajuan Guo, Wenbo Chen, Yuefang Lin, Yaqiu Zheng, Shaofang Yu, Wenxin Yan, Tao Su, Zhongqiu Liu*, Linlin Lu*. Screening tumor specificity targeted by arnicolide D, the active compound of Centipeda minima and molecular mechanism underlying by integrative pharmacology.Journal of Ethnopharmacology. 2022; 282:114583.
[5] Jingjing Yao, Min Huang, Qinghong Shen, Ming Ding, Shaofang Yu, Yajuan Guo, Yuefang Lin, Yaqiu Zheng, Wenbo Chen, Wenxin Yan, Zhongqiu Liu, Dawei Wang, Ming Hu*, Linlin Lu*. c-Myc-PD-L1 axis sustained gemcitabine-resistance in pancreatic cancer.Frontiers in Pharmacology. 2022;13:851512.
[6] Jingjing Yao, Zhenhua Du, Zibo Li, Shuhui Zhang, Yukun Lin, Haiyun Li, Lin Zhou, Yuehua Wang, Guixi Yan, Xianchuang Wu, Yongjian Duan, Gangjun Du*. 6-Gingerol as an arginase inhibitor prevents urethane-induced lung carcinogenesis by reprogramming tumor supporting M2 macrophages to M1 phenotype.Food Function. 2018; 9(9):4611-4620.
联系方式
办公地址:科研楼南108
邮箱:yaojingjing@sxtcm.edu.cn